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Analytical Chemistry, Advanced Course, 15 credits

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The course syllabus was confirmed by the Faculty board for graduate studies on 25 October 2017. Third cycle course, 15 credits.
This is a translation of the course syllabus approved in Swedish.

Learning outcomes

The course aims to provide advanced theoretical insight into commonly occurring modern separation techniques, such as chromatography, mass spectrometry and capillary electrophoresis.
The course also aims to develop the students’ ability to independently select and optimise appropriate separation techniques/methods and to provide a coherent overview of the subject.

On completion of the course the student will be able to:
• provide advanced explanations for the chromatographic principles and techniques that the course includes.
• explain the basics of mass spectrometry and capillary electrophoresis.
• describe the construction and function of different analytical instruments for the techniques treated on the course.
• modify and apply methods and techniques for chromatographic separation, for both quantitative and qualitative purposes.
• evaluate the choice of chromatographic technology for the separation of low molecular weight substances, based on the characteristics of the substances and the sample.
• compile results and present them orally and in writing.
• search, evaluate the relevance of, summarize and present scientific information in an assigned area.

Course content

Lectures: Advanced theoretical treatment of chromatographic separation and the underlying distribution and adsorption equilibria. Instrumentation and experimental technology for modern liquid chromatography and gas chromatography. Coupling gas chromatography and liquid chromatography to mass spectrometry. Basic orientation on capillary electrophoresis.

Laboratory work: Experimental technology for high resolution liquid chromatography and massspectrometry. Optimisation of HPLC systems with different combinations of mobile and stationary phases. Gas chromatography with capillary columns, injection techniques and the use of mass spectrometric detection.

Literature project: Chiral separations with oral and written presentation.

Teaching

Teaching comprises lectures and exercises treating theoretical aspects. Lectures are followed by mandatory laboratory work that is presented in writing and orally at a seminar. One week is devoted to a literature project that is presented orally at a seminar.

Assessment

In addition to written reports and oral seminars, the course is finally assessed with a written examination. A re-sit examination is offered soon after the examination to students who do not pass.

Grading scale

Possible grades are Pass and Fail. To pass the course, the student must pass the examination and pass the laborations and the literature project.

Language

The course is given in English.

Entry requirements

Admitted to PhD studies in Chemistry, Physics, or corresponding subject.

Additional information

The course is given also at advanced level, as KEMM06/KEMM76. Hence, this course cannot be credited together with KEMM06/KEMM76

Course responsible teacher and unit/division

Margareta Sandahl
Email: margareta.sandahl@chem.lu.se

Center for Analysis and Synthesis (CAS), KILU

Do you have questions? Please contact viveka.alfredsson@chem.lu.se